PandemieGrippaleV1, France, Analysis, bibRecord, 000544

Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom

Identifieur interne : 000544 ( France/Analysis ); précédent : 000543; suivant : 000545

Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom

Auteurs : R. G. Pebody [Royaume-Uni] ; N. Andrews [Royaume-Uni] ; D. M. Fleming [Royaume-Uni] ; J. Mcmenamin [Royaume-Uni] ; S. Cottrell [Royaume-Uni] ; B. Smyth [Royaume-Uni] ; H. Durnall [Royaume-Uni] ; C. Robertson [Royaume-Uni, France] ; W. Carman [Royaume-Uni] ; J. Ellis [Royaume-Uni] ; P. Sebastian-Pillai [Royaume-Uni] ; M. Zambon [Royaume-Uni] ; C. Kearns [Royaume-Uni] ; C. Moore [Royaume-Uni] ; D. Rh. Thomas [Royaume-Uni] ; J. M. Watson [Royaume-Uni]

Source :

Epidemiology and infection [ 0950-2688 ] ; 2013.

RBID : Pascal:13-0100987

Descripteurs français

Pascal (Inist)
- Virus grippal A, Age, Vaccin, Royaume-Uni, Epidémiologie, Grippe A.
Wicri :
- geographic : Royaume-Uni.
- topic : Vaccin.

English descriptors

KwdEn :
- Age, Epidemiology, Influenza A, Influenza A virus, United Kingdom, Vaccine.

Abstract

An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010. The test-negative case-control study design was employed based on patients consulting primary care. Overall TIV effectiveness, adjusted for age and month, against confirmed influenza A(H1N1)pdm 2009 infection was 56% (95% CI 42-66); age-specific adjusted VE was 87 % (95 % CI 45-97) in < 5-year-olds and 84 % (95 % CI 27-97) in 5- to 14-year-olds. Adjusted VE for PIV was only 28% (95% CI -6 to 51) overall and 72% (95 % CI 15-91) in < 5-year-olds. For confirmed influenza B infection, TIV effectiveness was 57% (95% CI 42-68) and in 5- to 14-year-olds 75% (95% CI 32-91). TIV provided moderate protection against the main circulating strains in 2010/2011, with higher protection in children. PIV administered during the previous season provided residual protection after 1 year, particularly in the < 5 years age group.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000360
to stream PascalFrancis, to step Curation: 001A66
to stream PascalFrancis, to step Checkpoint: 000334
to stream Main, to step Merge: 001931
to stream Main, to step Curation: 001902
to stream Main, to step Exploration: 001902
to stream France, to step Extraction: 000544

Links to Exploration step

Pascal:13-0100987

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom</title>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Public Health Agency Northern Ireland</s1>
<s2>Belfast</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Public Health Agency Northern Ireland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moore, C" sort="Moore, C" uniqKey="Moore C" first="C." last="Moore">C. Moore</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Public Health Wales</s1>
<s2>Cardiff</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Public Health Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomas, D Rh" sort="Thomas, D Rh" uniqKey="Thomas D" first="D. Rh." last="Thomas">D. Rh. Thomas</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Public Health Wales</s1>
<s2>Cardiff</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Public Health Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watson, J M" sort="Watson, J M" uniqKey="Watson J" first="J. M." last="Watson">J. M. Watson</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Health Protection Agency Health Protection Services- Colindale</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Epidemiology and infection</title>
<title level="j" type="abbreviated">Epidemiol. infect.</title>
<idno type="ISSN">0950-2688</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Epidemiology and infection</title>
<title level="j" type="abbreviated">Epidemiol. infect.</title>
<idno type="ISSN">0950-2688</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Epidemiology</term>
<term>Influenza A</term>
<term>Influenza A virus</term>
<term>United Kingdom</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term>
<term>Age</term>
<term>Vaccin</term>
<term>Royaume-Uni</term>
<term>Epidémiologie</term>
<term>Grippe A</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Royaume-Uni</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010. The test-negative case-control study design was employed based on patients consulting primary care. Overall TIV effectiveness, adjusted for age and month, against confirmed influenza A(H1N1)pdm 2009 infection was 56% (95% CI 42-66); age-specific adjusted VE was 87 % (95 % CI 45-97) in < 5-year-olds and 84 % (95 % CI 27-97) in 5- to 14-year-olds. Adjusted VE for PIV was only 28% (95% CI -6 to 51) overall and 72% (95 % CI 15-91) in < 5-year-olds. For confirmed influenza B infection, TIV effectiveness was 57% (95% CI 42-68) and in 5- to 14-year-olds 75% (95% CI 32-91). TIV provided moderate protection against the main circulating strains in 2010/2011, with higher protection in children. PIV administered during the previous season provided residual protection after 1 year, particularly in the < 5 years age group.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Grand Londres</li>
<li>Midlands de l'Ouest</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Birmingham</li>
<li>Londres</li>
<li>Lyon</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pebody, R G" sort="Pebody, R G" uniqKey="Pebody R" first="R. G." last="Pebody">R. G. Pebody</name>
</region>
<name sortKey="Andrews, N" sort="Andrews, N" uniqKey="Andrews N" first="N." last="Andrews">N. Andrews</name>
<name sortKey="Carman, W" sort="Carman, W" uniqKey="Carman W" first="W." last="Carman">W. Carman</name>
<name sortKey="Cottrell, S" sort="Cottrell, S" uniqKey="Cottrell S" first="S." last="Cottrell">S. Cottrell</name>
<name sortKey="Durnall, H" sort="Durnall, H" uniqKey="Durnall H" first="H." last="Durnall">H. Durnall</name>
<name sortKey="Ellis, J" sort="Ellis, J" uniqKey="Ellis J" first="J." last="Ellis">J. Ellis</name>
<name sortKey="Fleming, D M" sort="Fleming, D M" uniqKey="Fleming D" first="D. M." last="Fleming">D. M. Fleming</name>
<name sortKey="Kearns, C" sort="Kearns, C" uniqKey="Kearns C" first="C." last="Kearns">C. Kearns</name>
<name sortKey="Mcmenamin, J" sort="Mcmenamin, J" uniqKey="Mcmenamin J" first="J." last="Mcmenamin">J. Mcmenamin</name>
<name sortKey="Moore, C" sort="Moore, C" uniqKey="Moore C" first="C." last="Moore">C. Moore</name>
<name sortKey="Robertson, C" sort="Robertson, C" uniqKey="Robertson C" first="C." last="Robertson">C. Robertson</name>
<name sortKey="Robertson, C" sort="Robertson, C" uniqKey="Robertson C" first="C." last="Robertson">C. Robertson</name>
<name sortKey="Sebastian Pillai, P" sort="Sebastian Pillai, P" uniqKey="Sebastian Pillai P" first="P." last="Sebastian-Pillai">P. Sebastian-Pillai</name>
<name sortKey="Smyth, B" sort="Smyth, B" uniqKey="Smyth B" first="B." last="Smyth">B. Smyth</name>
<name sortKey="Thomas, D Rh" sort="Thomas, D Rh" uniqKey="Thomas D" first="D. Rh." last="Thomas">D. Rh. Thomas</name>
<name sortKey="Watson, J M" sort="Watson, J M" uniqKey="Watson J" first="J. M." last="Watson">J. M. Watson</name>
<name sortKey="Zambon, M" sort="Zambon, M" uniqKey="Zambon M" first="M." last="Zambon">M. Zambon</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Robertson, C" sort="Robertson, C" uniqKey="Robertson C" first="C." last="Robertson">C. Robertson</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom

Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom

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